Protein Chip Market Growth Analysis | 2022-2028

Market Insights

The Protein Chip Market was estimated at US$ 284.06 million in 2021 and is expected to grow at a CAGR of 4.41% during 2022-2028 to reach US$ ~348.20 million in 2028.

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What is a protein chip?

A protein chip is a biochip technology used in proteomics. It features a solid surface, typically a glass slide, where proteins or peptides are affixed in an array format. These immobilized proteins are used to study protein interactions, binding, and expression. Protein chips enable high-throughput protein analysis and biomarker discovery in research and diagnostics.

Market Dynamics

The rising cancer prevalence might be ascribed to the market's consistent revenue growth. Cancer is the largest cause of mortality worldwide, accounting for about one in every six deaths as of 2020, with over 10 million fatalities. Breast, lung, colon, rectum, and prostate cancers are the most common cancers diagnosed worldwide. In order to offer information on functional alterations within the proteome, reverse-phase protein microarray can detect altered cellular protein molecular networks and cell signaling pathways linked with human disorders, including cancer. Protein microarrays and protein chips are utilized in a variety of applications. These chips could be used to personalize medication, analyze the cancer signaling network, and improve prognosis and diagnosis procedures in the future.

Biomarkers are being evaluated as prospective approaches for early cancer detection, therapy monitoring, and prognosis evaluation, with advantages over computed tomography and biopsy in terms of procedural ease and cost. However, the bulk of cancer biomarkers now on the market have low sensitivity and specificity. As a result, there is an urgent need to develop cancer biomarkers. Protein arrays or protein chips are one of the most exciting technologies discovered during cancer proteomics research since they offer a variety of advantages such as reduced characteristics, high throughput, and sensitive detections.

Several investments/guidelines in the industry have been directed in recent years, which would boost the overall market. Some of them are:

• The increasing need for individualized diagnosis technologies is also propelling market revenue growth. Protein concentrations have been shown to more directly reflect the pathologic and physiological condition of tissue, organs, or cells. Protein microarrays, which only require a modest quantity of sample material, may also successfully profile DNA. Protein microarrays have established themselves as major tools in basic and applied research, with the first line of goods or equipment for in-vitro diagnostics being accessible on the market (IVD). Because of the numerous advantages afforded by employing a tiny amount of material, these microarrays have also proven to be reliable research instruments for screening, and they have proven to be beneficial in tailored and diagnostic medical applications. The protein microarray is based on an antigen-antibody response.

Segments Analysis

By Technique Type

The market is bifurcated into analytical microarrays, functional protein microarrays, and reverse-phase protein microarrays. Over the projected period, the analytical microarrays segment is expected to account for the majority of revenue. This is owing to the numerous advantages provided, as a result of which analytical microarrays are extensively employed in a variety of applications, such as analyzing a complex combination of proteins to identify specificities, binding affinities, and levels of protein expression. In this approach, a variety of antibodies, aptamers, or affibodies are put on a glass microscope slide, and the targeted protein is identified using direct labeling or a reporter antibody in a sandwich assay format.

The Functional Protein Microarrays (FPMs) market is predicted to increase rapidly throughout the forecast period. Full-length functional proteins or protein domains that have been purified independently form the basis of functional protein microarrays. Using a range of biochemical processes, researchers can explore protein biochemical properties such as protein-protein, protein-DNA, protein-drug, protein-peptide, and protein-lipid interactions, as well as enzyme-substrate correlations.

By Application Type

The protein chip market has been divided into diagnostics, proteomics, and antibody characterization. Because of the rising requirement to assess antibody class, binding kinetics, and epitope specificity, among other things, the antibody characterization sector is predicted to account for the biggest revenue share in the global market throughout the forecast period. Protein microarrays are often used in autoantibody profiling to assist in characterizing autoimmune diseases and some malignancies. Antibody characterization is also used in serological assays for allergy screening, which measure immune responses to a large number of antigens; cancer biomarker identification or validation, which probes high densities of known disease state tissue lysates with antibodies specific or cell types; and epitope mapping for antibody generation.

The diagnostics segment is expected to experience substantial revenue growth during the projection period. Protein chips help in clinical diagnostics and the diagnosis of complex disorders. Antibody-based immunoassays are the most common type of diagnostic assay, and technology for assessing such substances is continuously evolving due to advantages such as specificity. Protein chips can also identify biomarkers, which aid in the early detection of certain types of cancer.

By End-User Type

The research sector led the global market in terms of end users. The market has been divided into several sub-segments: hospitals, research institutes, pharmaceutical & biotechnology companies, and others. Over the projected period, the research institutes category is expected to account for a sizable revenue share. This is due to increased R&D (Research and Development) activities in proteomics. The study of proteins in terms of function, structure, expression, interaction, and modification in pathological and physiological states is referred to as proteomics. Protein chips are a major focus in the science of proteomics. One of the researchers' key goals is to create complete relational databases for metabolic and signal transduction pathways utilizing protein chips in the future.

Regional Analysis

The protein chip market is broken down geographically into areas like North America, Europe, Asia-Pacific, and the Rest of the World (RoW). North America is predicted to account for a significant revenue share in the worldwide protein chip market during the forecast period, owing to the region's well-established protein chip laboratories and research institutes. In the United States, for example, Yale researchers developed the world's first microarray chip for comprehensive protein profiling. The innovative protein chip has the potential to significantly advance research into protein function in creatures other than yeast, including humans. The majority of development occurs through protein interactions, and illnesses can emerge if proteins do not interact appropriately. This technology enables healthcare providers and researchers to comprehend the function of diverse proteins considerably faster than current methods. This is likely to open up new possibilities and opportunities for businesses and individuals.

Key Players

The following are the major players in the protein chip market:

• Agilent Technologies, Inc.
• Bio-Rad Laboratories, Inc.
• Danaher
• Illumina, Inc.
• Merck KGaA
• Arrayit Corporation
• PerkinElmer Inc.
• Quotient
• RayBiotech Life, Inc.
• Thermo Fischer Scientific, Inc

With the existence of numerous worldwide and international market competitors, the market is almost fully consolidated. The major players are implementing a variety of growth methods to improve their market presence, including alliances, contracts, collaborations, the introduction of new products, geographic expansions, mergers, and acquisitions. For example:

• Illumina and SomaLogic inked a final co-development agreement in January 2022 to bring the SomaScan Proteomics Assay to Illumina's current and future high-throughput next-generation sequencing (NGS) platforms. This collaboration will aid in the rapid growth of the proteomics market's high-throughput segment. With the volume and speed of Illumina NGS technology, researchers may more effectively and efficiently build biological links from genetic sequence (genotype) to cellular activity (phenotype), speeding the potential for therapeutic impact.
• Sengenics announced in March 2022 that the i-Ome Protein Array Kit is available for purchase. The i-Ome Protein Array Kit contains over 1600 immobilized, full-length, completely folded human proteins on high-density protein microarray slides. The new product makes the KREXTM technology more accessible to researchers working on autoantibody biomarker detection in autoimmune diseases.

Research Methodology

This report offers high-quality insights and is the outcome of a detailed research methodology comprising extensive secondary research, rigorous primary interviews with industry stakeholders, and validation and triangulation with Stratview Research’s internal database and statistical tools. More than 1,000 authenticated secondary sources, such as company annual reports, fact books, press releases, journals, investor presentations, white papers, patents, and articles, have been leveraged to gather the data. We conducted more than 15 detailed primary interviews with the market players across the value chain in all four regions and industry experts to obtain both qualitative and quantitative insights.

Report Features

This report provides market intelligence most comprehensively. The report structure has been kept such that it offers maximum business value. It provides critical insights into the market dynamics and will enable strategic decision-making for the existing market players as well as those willing to enter the market.

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